Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

被引：0

作者：

Jennifer C King

Jin Xu

John Wongvipat

Haley Hieronymus

Brett S Carver

David H Leung

Barry S Taylor

Chris Sander

Robert D Cardiff

Suzana S Couto

William L Gerald

Charles L Sawyers

机构：

[1] Human Oncology and Pathogenesis Program,Department of Physiology and Biophysics

[2] Memorial Sloan-Kettering Cancer Center,Department of Pathology and Laboratory Medicine

[3] Computational and Systems Biology Center,undefined

[4] Memorial Sloan-Kettering Cancer Center,undefined

[5] Weill Medical College of Cornell University,undefined

[6] Center for Comparative Medicine,undefined

[7] University of California,undefined

[8] Laboratory of Comparative Pathology,undefined

[9] Memorial Sloan-Kettering Cancer Center,undefined

[10] Howard Hughes Medical Institute,undefined

[11] Memorial Sloan-Kettering Cancer Center,undefined

来源：

Nature Genetics | 2009年 / 41卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Charles Sawyers and colleagues report that mice expressing a TMPRSS2-ERG fusion develop prostatic intraepithelial neoplasia, but only in the context of PI3-kinase pathway activation mediated by either Pten loss or Akt activation. They also find that human TMPRSS2-ERG–positive tumors are enriched for PTEN loss, suggesting that these two events cooperate in human prostate tumorigenesis.

引用

页码：524 / 526

页数：2

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