Synthesis of new pyrido[3,2-b][1,4]benzoxazines and -benzothiazines

被引：0

作者：

A. M. Starosotnikov

V. V. Ivanova

T. A. Klimova

N. G. Kolotyrkina

M. A. Bastrakov

机构：

[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry

[2] Dmitry Mendeleev University of Chemical Technology of Russia,undefined

来源：

Russian Chemical Bulletin | 2022年 / 71卷

关键词：

nucleophilic aromatic substitution; nitropyridines; pyrido[3,2-; ][1,4]benzoxazines; pyrido[3,2-; ][1,4]benzothiazines; -aminophenols;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

New pyrido[3,2-b][1,4]benzoxazines and pyrido[3,2-b][1,4]benzothiazines were synthesized by the base-mediated reactions of substituted 2-chloro-3-nitropyridines with o-amino(thio)phenols. The reactions involve a sequential nucleophilic substitution of the chlorine atom and the nitro group affected by either O,N- or S,N-binucleophile. In the case of aminothiophenols, the reaction proceeded via substitution of the chlorine atom followed by the Smiles rearrangement, and an intramolecular substitution of the nitro group by S-nucleophile.

引用

页码：126 / 130

页数：4

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