Synthesis and anti-inflammatory activity of 4-aryl-2-[(3-cyanothiophen-2-yl)amino]-4-oxobut-2-enoates

被引：0
|
作者：
Yu. O. Sharavyeva
I. A. Gorbunova
R. R. Makhmudov
D. A. Shipilovskikh
P. S. Silaichev
S. A. Shipilovskikh
机构：
[1] Perm State National Research University,School of Physics and Engineering
[2] Perm National Research Polytechnic University,undefined
[3] Peter the Great St. Petersburg Polytechnic University,undefined
[4] University ITMO,undefined
来源：
Russian Chemical Bulletin | 2023年 / 72卷
关键词：
Gewald thiophenes; 2,4-dioxobutanoic acids; 3-(thiophen-2-ylimino)furan-2(3; )-ones; anti-inflammatory activity; toxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
4-Aryl-4-oxo-2-(thiophen-2-ylamino)but-2-enoates bearing a cyano functional group at the thiophene ring were synthesized by the reaction of the corresponding substituted 3-(thiophen-2-ylamino)-3H-furan-2-ones with primary alcohols. Evaluation of biological activity and acute toxicity of the synthesized esters revealed their pronounced anti-inflammatory effect and low toxicity.
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页码：3005 / 3012
页数：7
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