11. The Impact of Dietary Fatty Acids on Fasting vs. Postprandial Glucose Homeostasis (87-OR)

We examined the impact of dietary fatty acids on measures of fasting and postprandial glucose homeostasis. Habitual dietary intake was collected in controls (n = 15), athletes (n = 14), obese (n = 23) and subjects with prediabetes (n = 10) and type 2 diabetes (n = 11) using the National Institutes of Health Diet History Questionnaire II. All subjects underwent an OGTT and a hyperinsulinemic-euglycemic clamp with infusion of [6,6-2H2]-glucose. Multiple regression was performed to examine age- and BMI-adjusted relationships between dietary fatty acids and measures of fasting plasma glucose (FPG) and postprandial glucose (2hPG).