Synthesis and Pharmacological Activity of 2,9-Disubstituted Imidazo[1,2-a]Benzimidazole Phenyl- and Alkylthiocarbamides

被引：0
|
作者：
V. A. Anisimova
O. N. Zhukovskaya
A. A. Spasov
V. A. Kuznetsova
V. A. Kosolapov
D. S. Yakovlev
O. A. Solov’eva
D. V. Sorotskii
A. A. Brigadirova
E. S. Vorob’ev
机构：
[1] Southern Federal University,Institute of Physical and Organic Chemistry
[2] Volgograd State Medical University,Research Institute of Pharmacology
[3] Volgograd State Medical University,Volgograd Medical Scientific Center
[4] Volgograd State Medical University,undefined
来源：
Pharmaceutical Chemistry Journal | 2016年 / 49卷
关键词：
2,9-disubstituted imidazo[1,2-; ]benzimidazole-3-thiocarbamides; synthesis; 5-HT; -agonist effect; AT; -antagonist activity; antioxidant properties; antiglycation activity;
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学科分类号：
摘要：
A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.
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页码：653 / 656
页数：3
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