SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 2,9-DISUBSTITUTED IMIDAZO[1,2-a]BENZIMIDAZOLE PHENYL- AND ALKYLTHIOCARBAMIDES

被引：4
|
作者：
Anisimova, V. A. [1 ]
Zhukovskaya, O. N. [1 ]
Spasov, A. A. [2 ,3 ,4 ]
Kuznetsova, V. A. [2 ,3 ]
Kosolapov, V. A. [2 ,3 ]
Yakovlev, D. S. [2 ,4 ]
Solov'eva, O. A. [2 ]
Sorotskii, D. V. [3 ]
Brigadirova, A. A. [2 ]
Vorob'ev, E. S. [2 ]
机构：
[1] Southern Fed Univ, Inst Phys & Organ Chem, Rostov Na Donu 344090, Russia
[2] Volgograd State Med Univ, Volgograd 400131, Russia
[3] Volgograd State Med Univ, Res Inst Pharmacol, Volgograd 400131, Russia
[4] Volgograd State Med Univ, Volgograd Med Sci Ctr, Volgograd 400131, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 49卷 / 10期
关键词：
2,9-disubstituted imidazo[1,2-a]benzimidazole-3-thiocarbamides; synthesis; 5-HT4-agonist effect; AT(1)-antagonist activity; antioxidant properties; antiglycation activity; SULFORAPHANE;
D O I：
10.1007/s11094-016-1346-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.
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收藏
页码：653 / 656
页数：4
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