Synthesis and Pharmacological Activity of 2,9-Disubstituted Imidazo[1,2-a]Benzimidazole Phenyl- and Alkylthiocarbamides

被引：0
|
作者：
V. A. Anisimova
O. N. Zhukovskaya
A. A. Spasov
V. A. Kuznetsova
V. A. Kosolapov
D. S. Yakovlev
O. A. Solov’eva
D. V. Sorotskii
A. A. Brigadirova
E. S. Vorob’ev
机构：
[1] Southern Federal University,Institute of Physical and Organic Chemistry
[2] Volgograd State Medical University,Research Institute of Pharmacology
[3] Volgograd State Medical University,Volgograd Medical Scientific Center
[4] Volgograd State Medical University,undefined
来源：
Pharmaceutical Chemistry Journal | 2016年 / 49卷
关键词：
2,9-disubstituted imidazo[1,2-; ]benzimidazole-3-thiocarbamides; synthesis; 5-HT; -agonist effect; AT; -antagonist activity; antioxidant properties; antiglycation activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.
引用
收藏
页码：653 / 656
页数：3
相关论文
共 50 条
  • [21] Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles
    A. A. Spasov
    O. N. Zhukovskaya
    A. A. Brigadirova
    H. S. A. Abbas
    V. A. Anisimova
    V. A. Sysoeva
    A. I. Rashchenko
    R. A. Litvinov
    O. Yu. Mayka
    D. A. Babkov
    A. S. Morkovnik
    Russian Chemical Bulletin, 2017, 66 : 1905 - 1912
  • [22] Iodine catalyzed synthesis of imidazo[1,2-a]pyrazine and imidazo[1,2-a]pyridine derivatives and their anticancer activity
    Krishnamoorthy, Rajavenkatesh
    Anaikutti, Parthiban
    RSC ADVANCES, 2023, 13 (51) : 36439 - 36454
  • [23] SYNTHESIS AND CONFORMATIONAL-ANALYSIS OF 2,9-DISUBSTITUTED 1-OXAQUINOLIZIDINES
    BORJESSON, L
    CSOREGH, I
    WELCH, CJ
    JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (10): : 2989 - 2999
  • [24] Synthesis and antiviral activity of imidazo[1,2-a]pyridines
    Lhassani, M
    Chavignon, O
    Chezal, JM
    Teulade, JC
    Chapat, JP
    Snoeck, R
    Andrei, G
    Balzarini, J
    De Clercq, E
    Gueiffier, A
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (03) : 271 - 274
  • [25] Synthesis and pharmacological activity of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo [1, 2-a]benzimidazole dihydrochlorides
    V. A. Anisimova
    A. A. Spasov
    V. A. Kosolapov
    I. E. Tolpygin
    V. I. Porotikov
    A. F. Kucheryavenko
    V. A. Sysoeva
    E. V. Tibirˈkova
    L. V. Elˈtsova
    Pharmaceutical Chemistry Journal, 2009, 43 : 491 - 494
  • [26] Research in the field of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acids
    Anisimova, V. A.
    Tolpygin, I. E.
    Spasov, A. A.
    Serdyuk, T. S.
    Sukhov, A. G.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2011, 37 (06) : 758 - 764
  • [27] Research in the field of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acids
    V. A. Anisimova
    I. E. Tolpygin
    A. A. Spasov
    T. S. Serdyuk
    A. G. Sukhov
    Russian Journal of Bioorganic Chemistry, 2011, 37 : 758 - 764
  • [28] STUDIES IN FIELD OF IMIDAZO[1,2-A]BENZIMIDAZOLE DERIVATIVES .11. SYNTHESIS OF 2-ARYLAMINO DERIVATIVES OF "9-METHYLIMIDAZO[1,2-A]BENZIMIDAZOLE
    SIMONOV, AM
    KUZMENKO, TA
    NACHINENNAYA, LG
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1975, (10): : 1394 - 1398
  • [29] Synthesis and Transformations of 9-Substituted Imidazo[1,2-a]benzimidazole-2-carbaldehydes
    T. A. Kuzʼmenko
    L. N. Divaeva
    A. S. Morkovnik
    Russian Journal of Organic Chemistry, 2020, 56 : 1160 - 1165
  • [30] Synthesis and Transformations of 9-Substituted Imidazo[1,2-a]benzimidazole-2-carbaldehydes
    Kuz'menko, T. A.
    Divaeva, L. N.
    Morkovnik, A. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (07) : 1160 - 1165
12345