Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

被引：0
|
作者：
Yohko Kitagawa
Naganari Ohkura
Yujiro Kidani
Alexis Vandenbon
Keiji Hirota
Ryoji Kawakami
Keiko Yasuda
Daisuke Motooka
Shota Nakamura
Motonari Kondo
Ichiro Taniuchi
Terumi Kohwi-Shigematsu
Shimon Sakaguchi
机构：
[1] WPI Immunology Frontier Research Center,Department of Experimental Immunology
[2] Osaka University,Department of Regeneration Science and Engineering
[3] Laboratory of Experimental Immunology,Department of Regeneration Science and Engineering
[4] Institute for Frontier Life and Medical Sciences,Department of Molecular Immunology
[5] Kyoto University,Life Sciences Division
[6] Immuno-Genomics Research Unit,undefined
[7] WPI Immunology Frontier Research Center,undefined
[8] Osaka University,undefined
[9] Laboratory of Integrative Biological Science,undefined
[10] Institute for Frontier Life and Medical Sciences,undefined
[11] Kyoto University,undefined
[12] Genome Information Research Center,undefined
[13] Research Institute for Microbial Diseases,undefined
[14] Osaka University,undefined
[15] School of Medicine,undefined
[16] Toho University,undefined
[17] Laboratory for Transcriptional Regulation,undefined
[18] Center for Integrative Medical Sciences,undefined
[19] RIKEN,undefined
[20] Lawrence Berkeley National Laboratory,undefined
来源：
Nature Immunology | 2017年 / 18卷
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学科分类号：
摘要：
Thymic regulatory T (Treg) precursors undergo a distinct developmental pathway. Sakaguchi and colleagues show the chromatin organizer Satb1 is required for establishing the super-enhancer chromatin landscape of Treg cell–specific signature genes before Foxp3 expression.
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页码：173 / 183
页数：10
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