Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

被引：0

作者：

Yohko Kitagawa

Naganari Ohkura

Yujiro Kidani

Alexis Vandenbon

Keiji Hirota

Ryoji Kawakami

Keiko Yasuda

Daisuke Motooka

Shota Nakamura

Motonari Kondo

Ichiro Taniuchi

Terumi Kohwi-Shigematsu

Shimon Sakaguchi

机构：

[1] WPI Immunology Frontier Research Center,Department of Experimental Immunology

[2] Osaka University,Department of Regeneration Science and Engineering

[3] Laboratory of Experimental Immunology,Department of Regeneration Science and Engineering

[4] Institute for Frontier Life and Medical Sciences,Department of Molecular Immunology

[5] Kyoto University,Life Sciences Division

[6] Immuno-Genomics Research Unit,undefined

[7] WPI Immunology Frontier Research Center,undefined

[8] Osaka University,undefined

[9] Laboratory of Integrative Biological Science,undefined

[10] Institute for Frontier Life and Medical Sciences,undefined

[11] Kyoto University,undefined

[12] Genome Information Research Center,undefined

[13] Research Institute for Microbial Diseases,undefined

[14] Osaka University,undefined

[15] School of Medicine,undefined

[16] Toho University,undefined

[17] Laboratory for Transcriptional Regulation,undefined

[18] Center for Integrative Medical Sciences,undefined

[19] RIKEN,undefined

[20] Lawrence Berkeley National Laboratory,undefined

来源：

Nature Immunology | 2017年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Thymic regulatory T (Treg) precursors undergo a distinct developmental pathway. Sakaguchi and colleagues show the chromatin organizer Satb1 is required for establishing the super-enhancer chromatin landscape of Treg cell–specific signature genes before Foxp3 expression.

引用

页码：173 / 183

页数：10

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