Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

被引:0
|
作者
Maria Pachetti
Bruna Marini
Francesca Benedetti
Fabiola Giudici
Elisabetta Mauro
Paola Storici
Claudio Masciovecchio
Silvia Angeletti
Massimo Ciccozzi
Robert C. Gallo
Davide Zella
Rudy Ippodrino
机构
[1] Elettra Sincrotrone Trieste - Area Science Park,Department of Physics
[2] University of Trieste,Department of Medicine, Surgery and Health Science
[3] University of Trieste,Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine
[4] Ulisse BioMed - Area Science Park,Medical Statistic and Molecular Epidemiology Unit
[5] University of Maryland,Institute of Human Virology, Department of Medicine, School of Medicine
[6] University of Biomedical Campus,undefined
[7] University of Maryland,undefined
[8] Co-founder and International Science Advisor - Global Virus Network,undefined
[9] Member of the Global Virus Network,undefined
关键词
SARS-CoV-2; COVID-19; Mutation; Drug resistance; RdRp; Europe; RNA-dependent-RNA-polymerase; Pneumonia; Viral mutagenesis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase
    Danda, Matej
    Klimesova, Anna
    Kuskova, Klara
    Dostalkova, Alzbeta
    Pagacova, Aneta
    Prchal, Jan
    Kapisheva, Marina
    Ruml, Tomas
    Rumlova, Michaela
    PROTEIN SCIENCE, 2024, 33 (09)
  • [32] Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase
    Li, Quanjie
    Yi, Dongrong
    Lei, Xiaobo
    Zhao, Jianyuan
    Zhang, Yongxin
    Cui, Xiangling
    Xiao, Xia
    Jiao, Tao
    Dong, Xiaojing
    Zhao, Xuesen
    Zeng, Hui
    Liang, Chen
    Ren, Lili
    Guo, Fei
    Li, Xiaoyu
    Wang, Jianwei
    Cen, Shan
    ACTA PHARMACEUTICA SINICA B, 2021, 11 (06) : 1555 - 1567
  • [33] A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase
    Zhao, Jianyuan
    Guo, SaiSai
    Yi, Dongrong
    Li, Quanjie
    Ma, Ling
    Zhang, Yongxin
    Wang, Jing
    Li, Xiaoyu
    Guo, Fei
    Lin, Rongtuan
    Liang, Chen
    Liu, Zhenlong
    Cen, Shan
    ANTIVIRAL RESEARCH, 2021, 190
  • [34] Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
    Yin, Wanchao
    Mao, Chunyou
    Luan, Xiaodong
    Shen, Dan-Dan
    Shen, Qingya
    Su, Haixia
    Wang, Xiaoxi
    Zhou, Fulai
    Zhao, Wenfeng
    Gao, Minqi
    Chang, Shenghai
    Xie, Yuan-Chao
    Tian, Guanghui
    Jiang, He-Wei
    Tao, Sheng-Ce
    Shen, Jingshan
    Jiang, Yi
    Jiang, Hualiang
    Xu, Yechun
    Zhang, Shuyang
    Zhang, Yan
    Xu, H. Eric
    SCIENCE, 2020, 368 (6498) : 1499 - +
  • [35] Bioactive Molecules of Tea as Potential Inhibitors for RNA-Dependent RNA Polymerase of SARS-CoV-2
    Bhardwaj, Vijay Kumar
    Singh, Rahul
    Sharma, Jatin
    Rajendran, Vidya
    Purohit, Rituraj
    Kumar, Sanjay
    FRONTIERS IN MEDICINE, 2021, 8
  • [36] Emerging genetic diversity of SARS-CoV-2 RNA dependent RNA polymerase (RdRp) alters its B-cell epitopes
    Kumar, Sushant
    Kumari, Khushboo
    Azad, Gajendra Kumar
    BIOLOGICALS, 2022, 75 : 29 - 36
  • [37] Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase
    Xu, Tiantian
    Zhang, Lu
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2023, 21 : 4385 - 4394
  • [38] SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
    Vicenti, Ilaria
    Zazzi, Maurizio
    Saladini, Francesco
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2021, 31 (04) : 325 - 337
  • [39] Biostructural Models for the Binding of Nucleoside Analogs to SARS-CoV-2 RNA-Dependent RNA Polymerase
    Prussia, Andrew J.
    Chennamadhavuni, Spandan
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2021, 61 (03) : 1402 - 1411
  • [40] Water Soluble Tocopherol Derivatives Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase
    Harrod, K. S.
    Pacl, H. T.
    Tipper, J. L.
    Ahmad, S.
    Ahmad, A.
    Holder, G.
    Petit, C.
    Green, T.
    Steyn, A. J. C.
    Might, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205