Discovery and characterization of chromatin states for systematic annotation of the human genome

被引：0
|
作者：
Jason Ernst
Manolis Kellis
机构：
[1] MIT Computer Science and Artificial Intelligence Laboratory,
[2] Broad Institute of MIT and Harvard,undefined
来源：
Nature Biotechnology | 2010年 / 28卷
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学科分类号：
摘要：
Which of the possible combinations of epigenetic marks have biological significance is a major question in epigenetics. Analyzing data from human T-cells, Ernst and Kellis discover 51 distinct, recurring combinations of histone modifications that can be correlated with the functional annotations of the underlying DNA sequences.
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页码：817 / 825
页数：8
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