Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis

被引：0
|
作者：
Ji-Chan Jang
Yong-Gyun Jung
Jungil Choi
Hyunju Jung
Sungweon Ryoo
机构：
[1] Gyeongsang National University,Molecular Mechanisms of Antibiotics, Division of Life Science
[2] Gyeongsang National University,Research Institute of Life Sciences
[3] Myongji University,Interdisciplinary Program of Biomodulation, College of Natural Science
[4] Myongji University,Myongji Bioefficiency Research Centre
[5] Myongji University,Center for Nutraceutical and Pharmaceutical Materials
[6] Northwestern University,Department of Materials Science and Engineering
[7] Korean Institute of Tuberculosis,undefined
[8] Korean National Tuberculosis Association,undefined
来源：
Journal of Microbiology | 2017年 / 55卷
关键词：
bedaquiline; totally drug resistant ;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study aimed to provide information that bedaquilline is significantly effective for treatment of totally drug resistant (TDR) Mycobacterium tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system. Time-lapse images of single bacterial cells under culture conditions with different concentrations of bedaquiline were analysed by image processing software to determine minimum inhibitory concentrations (MICs). Bedaquiline inhibited the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. The results of the present study demonstrate that bedaquiline, newly approved by the United States Food and Drug Administration (FDA), may offer therapeutic solutions for TDR-TB.
引用
收藏
页码：483 / 487
页数：4
相关论文
共 50 条
  • [31] Acquisition of bedaquiline resistance by extensively drug-resistant Mycobacterium tuberculosis strain of Central Asian Outbreak clade
    Mokrousov, I.
    Akhmedova, G.
    Polev, D.
    Molchanov, V.
    Vyazovaya, A.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (10) : 1295 - 1297
  • [32] Combined treatment of drug-resistant tuberculosis with bedaquiline and delamanid: a systematic review
    Pontali, Emanuele
    Sotgiu, Giovanni
    Tiberi, Simon
    Tadolini, Marina
    Visca, Dina
    D'Ambrosio, Lia
    Centis, Rosella
    Spanevello, Antonio
    Migliori, Giovanni Battista
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2018, 52 (01)
  • [33] Extensively drug-resistant tuberculosis: early access to bedaquiline for a UK patient
    van Halsema, Clare
    Humphreys, Susan
    Bonington, Alec
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2014, 43 (01) : 292 - 294
  • [34] Pharmacokinetic interaction between bedaquiline and clofazimine in patients with drug-resistant tuberculosis
    Maartens, G.
    Brill, M. J. E.
    Pandie, M.
    Svensson, E. M.
    [J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2018, 22 (01) : 26 - +
  • [35] Use of bedaquiline in the treatment of a patient with extensively drug-resistant pulmonary tuberculosis
    Kostanta, Soultana
    Manika, Katerina
    Papavasileiou, Apostolos
    Ioannidis, Panagiotis
    Papadaki, Eleni
    Zarogoulidis, Konstantinos
    Kioumis, Ioannis
    [J]. PNEUMON, 2016, 29 (01): : 53 - 57
  • [36] Efficacy of Tuberculosis Treatment in Patients with Drug-Resistant Tuberculosis with the Use of Bedaquiline: The Experience of the Russian Federation
    Starshinova, Anna
    Dovgalyk, Irina
    Belyaeva, Ekaterina
    Glushkova, Anzhela
    Osipov, Nikolay
    Kudlay, Dmitry
    [J]. ANTIBIOTICS-BASEL, 2022, 11 (11):
  • [37] Effect of bedaquiline on mortality in South African patients with drug-resistant tuberculosis
    Yates, Tom A.
    [J]. LANCET RESPIRATORY MEDICINE, 2018, 6 (12): : E56 - E56
  • [38] Experiences in the introduction of bedaquiline pretomanid linezolid for drug-resistant tuberculosis in Kyrgyzstan
    Myrzaliev, B.
    Ahmatov, M.
    Duishekeeva, A.
    Kulzhabaeva, A.
    Kadyrov, A.
    Toktogonova, A.
    Abdulaeva, G.
    Wares, D. F.
    Mirtskhulava, V.
    Mbenga, M.
    Slyzkyi, A.
    Foraida, S.
    Diachenko, M.
    Juneja, S.
    Turdumambetova, G.
    Musaeva, A.
    Gebhard, A.
    [J]. JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES, 2024, 36
  • [39] Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis in China
    Han, X.
    Chen, X.
    Sha, W.
    Zhang, X.
    Qiu, L.
    Wang, J.
    Wu, G.
    Yao, L.
    Lv, Y.
    Zhang, X.
    Zhou, J.
    Tang, S.
    Chu, N.
    [J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2020, 24 (08) : 789 - +
  • [40] A cost comparison of amikacin therapy with bedaquiline, for drug-resistant tuberculosis in the UK
    Manalan, Kavina
    Green, Nathan
    Arnold, Amber
    Cooke, Graham S.
    Dedicoat, Martin
    Lipman, Marc
    Loyse, Angela
    Harrison, Tom S.
    Kon, Onn Min
    [J]. JOURNAL OF INFECTION, 2020, 80 (01) : 38 - 41
12345