Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis

被引：0

作者：

Ji-Chan Jang

Yong-Gyun Jung

Jungil Choi

Hyunju Jung

Sungweon Ryoo

机构：

[1] Gyeongsang National University,Molecular Mechanisms of Antibiotics, Division of Life Science

[2] Gyeongsang National University,Research Institute of Life Sciences

[3] Myongji University,Interdisciplinary Program of Biomodulation, College of Natural Science

[4] Myongji University,Myongji Bioefficiency Research Centre

[5] Myongji University,Center for Nutraceutical and Pharmaceutical Materials

[6] Northwestern University,Department of Materials Science and Engineering

[7] Korean Institute of Tuberculosis,undefined

[8] Korean National Tuberculosis Association,undefined

来源：

Journal of Microbiology | 2017年 / 55卷

关键词：

bedaquiline; totally drug resistant ;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study aimed to provide information that bedaquilline is significantly effective for treatment of totally drug resistant (TDR) Mycobacterium tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system. Time-lapse images of single bacterial cells under culture conditions with different concentrations of bedaquiline were analysed by image processing software to determine minimum inhibitory concentrations (MICs). Bedaquiline inhibited the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. The results of the present study demonstrate that bedaquiline, newly approved by the United States Food and Drug Administration (FDA), may offer therapeutic solutions for TDR-TB.

引用

页码：483 / 487

页数：4

共 50 条

[21] Adverse effects of bedaquiline in patients with extensively drug-resistant tuberculosis
Gaida, Razia
Truter, Ilse
Peters, Charles A.
SOUTHERN AFRICAN JOURNAL OF INFECTIOUS DISEASES, 2020, 35 (01)
[22] Clinical Access to Bedaquiline Programme for the treatment of drug-resistant tuberculosis
Conradie, F.
Meintjes, G.
Hughes, J.
Maartens, G.
Ferreira, H.
Siwendu, S.
Master, I.
Ndjeka, N.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL, 2014, 104 (03): : 164 - 166
[23] PREDICTORS OF DRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS
AITKEN, ML
SPARKS, R
ANDERSON, K
ALBERT, RK
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1984, 130 (05): : 831 - 833
[24] Deciphering an outbreak of drug-resistant Mycobacterium tuberculosis
Dahle, UR
Sandven, P
Heldal, E
Mannsaaker, T
Caugant, DA
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (01) : 67 - 72
[25] Extensively drug-resistant Mycobacterium tuberculosis, India
Mondal, Rajesh
Jain, Amita
EMERGING INFECTIOUS DISEASES, 2007, 13 (09) : 1429 - 1431
[26] Drug-resistant Mycobacterium tuberculosis in Argentinian children
Berberian, Griselda
Casimir, Lidia
Lovadina, Laura
Verdaguer, Virginia
Rosanova, Maria Teresa
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2008, 12 : S45 - S45
[27] IMMUNODIAGNOSIS OF DRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS
YEVDOKIMOV, VN
LABORATORNOE DELO, 1990, (08): : 67 - 70
[28] Surveillance of drug-resistant Mycobacterium tuberculosis in The Gambia
Adegbola, RA
Hill, P
Baldeh, I
Otu, J
Sarr, R
Sillah, J
Lienhardt, C
Corrah, T
Manneh, K
Drobniewski, F
McAdam, KPWJ
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2003, 7 (04) : 390 - 393
[29] India reports cases of totally drug-resistant tuberculosis
Loewenberg, Samuel
LANCET, 2012, 379 (9812): : 205 - 205
[30] PRIMARY DRUG-RESISTANT TUBERCULOSIS IN CHILDREN - EMERGENCE OF PRIMARY DRUG-RESISTANT STRAINS OF MYCOBACTERIUM-TUBERCULOSIS TO RIFAMPIN
STEINER, P
RAO, M
MITCHELL, M
STEINER, M
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1986, 134 (03): : 446 - 448

← 1 2 3 4 5 →