Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis

被引：0

作者：

Ji-Chan Jang

Yong-Gyun Jung

Jungil Choi

Hyunju Jung

Sungweon Ryoo

机构：

[1] Gyeongsang National University,Molecular Mechanisms of Antibiotics, Division of Life Science

[2] Gyeongsang National University,Research Institute of Life Sciences

[3] Myongji University,Interdisciplinary Program of Biomodulation, College of Natural Science

[4] Myongji University,Myongji Bioefficiency Research Centre

[5] Myongji University,Center for Nutraceutical and Pharmaceutical Materials

[6] Northwestern University,Department of Materials Science and Engineering

[7] Korean Institute of Tuberculosis,undefined

[8] Korean National Tuberculosis Association,undefined

来源：

Journal of Microbiology | 2017年 / 55卷

关键词：

bedaquiline; totally drug resistant ;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study aimed to provide information that bedaquilline is significantly effective for treatment of totally drug resistant (TDR) Mycobacterium tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system. Time-lapse images of single bacterial cells under culture conditions with different concentrations of bedaquiline were analysed by image processing software to determine minimum inhibitory concentrations (MICs). Bedaquiline inhibited the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. The results of the present study demonstrate that bedaquiline, newly approved by the United States Food and Drug Administration (FDA), may offer therapeutic solutions for TDR-TB.

引用

页码：483 / 487

页数：4

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