Human cathelicidin LL-37 – Does it influence the homeostatic imbalance in mental disorders?

被引:0
|
作者
ELŻBIETA KOZŁOWSKA
ADAM WYSOKIŃSKI
KAROL MAJEWSKI
JUSTYNA AGIER
ALEKSANDRA MARGULSKA
EWA BRZEZIŃSKA-BŁASZCZYK
机构
[1] Medical University of Lodz,Department of Experimental Immunology
[2] Medical University of Lodz,Department of Old Age Psychiatry and Psychotic Disorders
[3] Pulmonary Disease Hospital,undefined
来源
Journal of Biosciences | 2018年 / 43卷
关键词
Antimicrobial peptides; bacterial pneumonia; bipolar disorder; cathelicidin LL-37; pulmonary tuberculosis; schizophrenia;
D O I
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中图分类号
学科分类号
摘要
In addition to killing pathogens and influencing immunological processes, cathelicidin LL-37 is a multifunctional host defense peptide with a role in homeostasis. It has been suggested that imbalances in homeostatic signaling from inflammatory/immune, endocrine and metabolic cascades and oxidative stress may partially contribute to the pathogenesis of mental disorders. The purpose of the study was to identify any differences in LL-37 levels between patients with schizophrenia, euthymic bipolar disorder, bacterial pneumonia, pulmonary tuberculosis, and healthy controls. Thirty-five patients with chronic paranoid schizophrenia, 40 patients with chronic, euthymic bipolar disorder, 30 patients with bacterial pneumonia, 32 patients with pulmonary tuberculosis, and 38 healthy volunteers were included in this study. The patients with schizophrenia demonstrated a significantly lower level of LL-37 than those with bipolar disorder (p=0.006) and those with pulmonary TB (p<0.001). Significant differences in LL-37 levels were found between patients with bipolar disorder, bacterial pneumonia (p<0.001) and pulmonary TB (p=0.004). Our findings suggest that changes observed in the serum level of LL-37 in psychiatric patients enrolled in this study could be a result of homeostatic imbalance.
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页码:321 / 327
页数:6
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