Low serum levels of cathelicidin LL-37 in leprosy

被引：18

作者：

Matzner, Michael ^{[2
]}

Al Samie, Abdul Rahim ^{[3
]}

Winkler, Heide-Maria ^{[1
]}

Nemeth, Johannes ^{[1
]}

Grasnek, Andreas ^{[1
]}

Indra, Alexander ^{[4
]}

Bieglmayer, Christian ^{[5
,6
]}

Winkler, Stefan ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Trop Med, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Orthopaed Surg, A-1090 Vienna, Austria

[3] Minist Hlth & Populat, Natl Leprosy Eliminat Program, Taizi, Yemen

[4] Austrian Agcy Hlth & Food Safety AGES, A-1096 Vienna, Austria

[5] Med Univ Vienna, Inst Clin Med, A-1090 Vienna, Austria

[6] Med Univ Vienna, Chem Lab Diagnost, A-1090 Vienna, Austria

来源：

ACTA TROPICA | 2011年 / 117卷 / 01期

关键词：

Leprosy; M; leprae; Cathelicidin; Vitamin D3; MYCOBACTERIUM-TUBERCULOSIS; ANTIMICROBIAL PEPTIDES; DEFICIENCY; EXPRESSION; INFECTION; RESPONSES; DEFENSE; DISEASE; HCAP18; SKIN;

D O I：

10.1016/j.actatropica.2010.09.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The antimicrobial peptide cathelicidin LL-37 possesses antituberculous activity, its association with other mycobacterial diseases, such as leprosy, is unknown. We studied serum cathelicidin and 25OH-vitamin D3 levels in 29 leprosy patients and 19 healthy individuals from Yemen. Cathelicidin levels were significantly lower in both treated (n = 15) and untreated leprosy patients (n = 14) when compared to controls (P < 0.001). Within leprosy patients, levels were lower in those who very recently developed disease (untreated group) when compared to already treated patients (P < 0.05). 25OH-vitamin D3 levels were not different between groups. The results suggest a potential association of cathelicidin LL-37 with Mycobacterium leprae infection. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：56 / 59

页数：4

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