Synthesis and antiviral activity of lupane triterpenoids with modified cycle E

被引：0
|
作者：
O. B. Flekhter
N. I. Medvedeva
O. S. Kukovinets
L. V. Spirikhin
E. G. Galkin
F. Z. Galin
D. G. Golovanov
N. I. Pavlova
O. V. Savinova
E. I. Boreko
G. A. Tolstikov
机构：
[1] Russian Academy of Sciences,Institute of Organic Chemistry, Ufa Scientific Center
[2] Russian Academy of Sciences,Nesmeyanov Institute of Organoelement Compounds
[3] State Research Institute of Epidemiology and Microbiology,Vorozhtsov Institute of Organic Chemistry, Siberian Division
[4] Russian Academy of Sciences,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2007年 / 33卷
关键词：
lupane triterpenoids; ozonolysis; antiviral activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A reductive transformation of the peroxide products of ozonolysis of derivatives of 3β-O-acetyl-22(17→28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex.
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页码：584 / 588
页数：4
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