Synthesis and hepatoprotective activity of esters of the lupane group triterpenoids

被引：0
|
作者：
Flekhter, OB
Karachurina, LT
Poroikov, VV
Nigmatullina, LP
Baltina, LA
Zarudii, FS
Davydova, VA
Spirikhin, LV
Baikova, IP
Galin, FZ
Tolstikov, GA
机构：
[1] Russian Acad Sci, Ufa Sci Ctr, Inst Organ Chem, Ufa 450054, Bashkortostan, Russia
[2] Russian Acad Med Sci, Inst Biomed Chem, Moscow 119832, Russia
来源：
BIOORGANICHESKAYA KHIMIYA | 2000年 / 26卷 / 03期
关键词：
lupane group triterpenoid esters; computer prediction of biological activity; hepatoprotective activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bis-hemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol.
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页码：215 / 223
页数：9
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