Negative regulation of TGF-β signaling in development

被引：0
|
作者：
Ye Guang CHEN
An Ming MENG
机构：
[1] The State Key Laboratory of Biomembrane and Membrane Biotechnology,Department of Biological Sciences and Biotechnology
[2] Tsinghua University,undefined
来源：
Cell Research | 2004年 / 14卷
关键词：
TGF-β; BMP; Nodal; Activin; antagonist; development; negative regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-β signaling with focus on its roles in vertebrate development.
引用
收藏
页码：441 / 449
页数：8
相关论文
共 50 条
  • [21] Regulation of osteoblast differentiation by TGF-β signaling
    Derynek, R
    Alliston, T
    Kang, JS
    Skillington, J
    Lorget, F
    Choy, L
    FASEB JOURNAL, 2004, 18 (04): : A404 - A405
  • [22] Regulation of TGF-β signaling and vascular diseases
    Miyazono, K.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 718 - 718
  • [23] Regulation of cell proliferation by TGF-β signaling
    Liu, XD
    Cheung, TH
    Macdonald, M
    Bjorkman, KK
    Collins, JP
    Shannon, KW
    Knuesel, M
    FASEB JOURNAL, 2003, 17 (05): : A790 - A790
  • [24] Negative regulation of TGF-β signaling by Smurf2 in growth plate chondrocytes
    Mulcahey, MK
    Pirri, M
    Dong, Y
    Wu, Q
    Schwarz, EM
    Puzas, JE
    O'Keefe, RJ
    Drissi, H
    Rosier, RN
    Zuscik, MJ
    JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S351 - S351
  • [25] Ski and SnoN:: negative regulators of TGF-β signaling
    Luo, KX
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (01) : 65 - 70
  • [26] TGF-β signaling:: positive and negative effects on tumorigenesis
    Wakefield, LM
    Roberts, AB
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (01) : 22 - 29
  • [27] Negative Feedback and Crosstalk in the TGF-β Signaling Pathway
    Saiz, Leonor
    Nicklas, Daniel
    Mei, Qian
    Pantoja, Victor
    BIOPHYSICAL JOURNAL, 2014, 106 (02) : 377A - 377A
  • [28] Specificity, diversity, and regulation in TGF-β superfamily signaling
    Piek, E
    Heldin, CH
    Ten Dijke, P
    FASEB JOURNAL, 1999, 13 (15): : 2105 - 2124
  • [29] The regulation of TGF-β/SMAD signaling by protein deubiquitination
    Juan Zhang
    Xiaofei Zhang
    Feng Xie
    Zhengkui Zhang
    Hans van Dam
    Long Zhang
    Fangfang Zhou
    Protein & Cell, 2014, 5 (07) : 503 - 517
  • [30] TGF-β signaling in development and disease Preface
    Massague, Joan
    FEBS LETTERS, 2012, 586 (14) : 1833 - 1833
12345