Ski and SnoN:: negative regulators of TGF-β signaling

被引：169
|
作者：
Luo, KX
机构：
[1] Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.gde.2003.11.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ski and SnoN are unique proto-oncoproteins in that they can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. Recent studies using in vitro and in vivo approaches have begun to unravel the complex roles of Ski and SnoN in tumorigenesis and embryonic development. The identification of Ski and SnoN as important negative regulators of signal transduction by the transforming growth factor-beta superfamily of cytokines provides a valuable molecular basis for the complex functions of Ski and SnoN.
引用
收藏
页码：65 / 70
页数：6
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