Ski/Sno and TGF-β signaling

被引：186
|
作者：
Liu, XD
Sun, Y
Weinberg, RA
Lodish, HF
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
[3] Univ Rochester, Med Ctr, Ctr Canc Biol, Rochester, NY 14642 USA
[4] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2001年 / 12卷 / 01期
关键词：
TGF-beta signaling; Smads; Ski; Sno; cell cycle; p27; cdks; tumorigenesis; N-CoR; HDAC;
D O I：
10.1016/S1359-6101(00)00031-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor-beta is a potent inhibitor of epithelial cell proliferation. Proteins involved in TGF-beta signaling are bona fide tumor suppressors and many tumor cells acquire the ability to escape TGF-beta growth inhibition through the loss of key signaling transducers in the pathway or through the activation of oncogenes. Recent studies indicate that there is a specific connection between the TGF-beta signaling pathway and the Ski/SnoN family of oncoproteins. We summarize evidence that Ski and SnoN directly associate with Smad proteins and block the ability of the Smads to activate expression of many if not all TGF-beta -responsive genes. This appears to cause abrogation of TGF-beta growth inhibition in epithelial cells. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1 / 8
页数：8
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