MLL/AF-1p Fusion in Therapy-Related Early Pre-B Acute Lymphoblastic Leukemia with t(1;11)(p32;q23) Translocation Developing in the Relapse Phase of Acute Promyelocytic Leukemia

被引：0
|
作者：
Takayuki Tsujioka
Hideho Wada
Shunji Yamamori
Takemi Otsuki
Sinichiro Suemori
Toshinori Kondo
Hidekazu Nakanishi
Yoshimasa Suetsugu
Makoto Mikami
Takashi Sugihara
机构：
[1] Kawasaki Medical School,Division of Hematology, Department of Medicine
[2] Mitsubishi Kagaku Bio-clinical Laboratories,Department of Hygiene
[3] Kawasaki Medical School,undefined
来源：
International Journal of Hematology | 2003年 / 78卷
关键词：
Therapy-related AL; FISH;
D O I：
暂无
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学科分类号：
摘要：
We report the development of therapy-related early pre-B acute lymphoblastic leukemia in a patient administered a topoisomerase II inhibitor, etoposide, a consolidation therapy agent for acute promyelocytic leukemia. Our case is of interest because of simultaneous relapse of the original leukemia and onset of therapy-related leukemia and relatively rare t(1;11) (p32;q23) translocation with confirmedMLL/AF- 1p fusion. This case suggests that careful monitoring forMLL gene rearrangements is necessary after administration of topoisomerase II inhibitors.
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页码：439 / 442
页数：3
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