MLL/AF-1p Fusion in Therapy-Related Early Pre-B Acute Lymphoblastic Leukemia with t(1;11)(p32;q23) Translocation Developing in the Relapse Phase of Acute Promyelocytic Leukemia

被引：0

作者：

Takayuki Tsujioka

Hideho Wada

Shunji Yamamori

Takemi Otsuki

Sinichiro Suemori

Toshinori Kondo

Hidekazu Nakanishi

Yoshimasa Suetsugu

Makoto Mikami

Takashi Sugihara

机构：

[1] Kawasaki Medical School,Division of Hematology, Department of Medicine

[2] Mitsubishi Kagaku Bio-clinical Laboratories,Department of Hygiene

[3] Kawasaki Medical School,undefined

来源：

International Journal of Hematology | 2003年 / 78卷

关键词：

Therapy-related AL; FISH;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We report the development of therapy-related early pre-B acute lymphoblastic leukemia in a patient administered a topoisomerase II inhibitor, etoposide, a consolidation therapy agent for acute promyelocytic leukemia. Our case is of interest because of simultaneous relapse of the original leukemia and onset of therapy-related leukemia and relatively rare t(1;11) (p32;q23) translocation with confirmedMLL/AF- 1p fusion. This case suggests that careful monitoring forMLL gene rearrangements is necessary after administration of topoisomerase II inhibitors.

引用

页码：439 / 442

页数：3

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