Spatial genomic heterogeneity within localized, multifocal prostate cancer

被引：0
|
作者：
Paul C Boutros
Michael Fraser
Nicholas J Harding
Richard de Borja
Dominique Trudel
Emilie Lalonde
Alice Meng
Pablo H Hennings-Yeomans
Andrew McPherson
Veronica Y Sabelnykova
Amin Zia
Natalie S Fox
Julie Livingstone
Yu-Jia Shiah
Jianxin Wang
Timothy A Beck
Cherry L Have
Taryne Chong
Michelle Sam
Jeremy Johns
Lee Timms
Nicholas Buchner
Ada Wong
John D Watson
Trent T Simmons
Christine P'ng
Gaetano Zafarana
Francis Nguyen
Xuemei Luo
Kenneth C Chu
Stephenie D Prokopec
Jenna Sykes
Alan Dal Pra
Alejandro Berlin
Andrew Brown
Michelle A Chan-Seng-Yue
Fouad Yousif
Robert E Denroche
Lauren C Chong
Gregory M Chen
Esther Jung
Clement Fung
Maud H W Starmans
Hanbo Chen
Shaylan K Govind
James Hawley
Alister D'Costa
Melania Pintilie
Daryl Waggott
Faraz Hach
机构：
[1] Ontario Institute for Cancer Research,Department of Medical Biophysics
[2] University of Toronto,Department of Pharmacology and Toxicology
[3] University of Toronto,Department of Pathology and Laboratory Medicine
[4] Ontario Cancer Institute,Department of Biostatistics
[5] Princess Margaret Cancer Centre,Department of Radiation Oncology
[6] University Health Network,Department of Radiotherapy
[7] Toronto General Hospital,Division of Genetics and Epidemiology
[8] University Health Network,Department of Biological Sciences
[9] School of Computing Science,Department of Surgical Oncology
[10] Simon Fraser University,Department of Pathology
[11] Princess Margaret Cancer Centre,Division of Urology
[12] University Health Network,Department of Pathology
[13] University of Toronto,Department of Computer Science
[14] Maastricht University,Department of Urologic Sciences
[15] The Institute of Cancer Research,undefined
[16] University of East Anglia,undefined
[17] School of Medicine,undefined
[18] University of East Anglia,undefined
[19] Royal Marsden National Health Service (NHS) Foundation Trust,undefined
[20] Urological Research Laboratory,undefined
[21] Cancer Research UK Cambridge Research Institute,undefined
[22] University of Cambridge,undefined
[23] Addenbrooke's Hospital,undefined
[24] Laval University,undefined
[25] Princess Margaret Cancer Centre,undefined
[26] University Health Network,undefined
[27] University of British Columbia,undefined
[28] University of British Columbia,undefined
[29] Vancouver,undefined
[30] British Columbia Cancer Agency Research Centre,undefined
[31] University of British Columbia,undefined
[32] Laboratory for Advanced Genome Analysis,undefined
[33] Vancouver Prostate Centre,undefined
来源：
Nature Genetics | 2015年 / 47卷
关键词：
D O I：
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中图分类号：
学科分类号：
摘要：
Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneous, and they identify a novel recurrent amplification of MYCL1.
引用
收藏
页码：736 / 745
页数：9
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