Spatial genomic heterogeneity within localized, multifocal prostate cancer

被引：0

作者：

Paul C Boutros

Michael Fraser

Nicholas J Harding

Richard de Borja

Dominique Trudel

Emilie Lalonde

Alice Meng

Pablo H Hennings-Yeomans

Andrew McPherson

Veronica Y Sabelnykova

Amin Zia

Natalie S Fox

Julie Livingstone

Yu-Jia Shiah

Jianxin Wang

Timothy A Beck

Cherry L Have

Taryne Chong

Michelle Sam

Jeremy Johns

Lee Timms

Nicholas Buchner

Ada Wong

John D Watson

Trent T Simmons

Christine P'ng

Gaetano Zafarana

Francis Nguyen

Xuemei Luo

Kenneth C Chu

Stephenie D Prokopec

Jenna Sykes

Alan Dal Pra

Alejandro Berlin

Andrew Brown

Michelle A Chan-Seng-Yue

Fouad Yousif

Robert E Denroche

Lauren C Chong

Gregory M Chen

Esther Jung

Clement Fung

Maud H W Starmans

Hanbo Chen

Shaylan K Govind

James Hawley

Alister D'Costa

Melania Pintilie

Daryl Waggott

Faraz Hach

机构：

[1] Ontario Institute for Cancer Research,Department of Medical Biophysics

[2] University of Toronto,Department of Pharmacology and Toxicology

[3] University of Toronto,Department of Pathology and Laboratory Medicine

[4] Ontario Cancer Institute,Department of Biostatistics

[5] Princess Margaret Cancer Centre,Department of Radiation Oncology

[6] University Health Network,Department of Radiotherapy

[7] Toronto General Hospital,Division of Genetics and Epidemiology

[8] University Health Network,Department of Biological Sciences

[9] School of Computing Science,Department of Surgical Oncology

[10] Simon Fraser University,Department of Pathology

[11] Princess Margaret Cancer Centre,Division of Urology

[12] University Health Network,Department of Pathology

[13] University of Toronto,Department of Computer Science

[14] Maastricht University,Department of Urologic Sciences

[15] The Institute of Cancer Research,undefined

[16] University of East Anglia,undefined

[17] School of Medicine,undefined

[18] University of East Anglia,undefined

[19] Royal Marsden National Health Service (NHS) Foundation Trust,undefined

[20] Urological Research Laboratory,undefined

[21] Cancer Research UK Cambridge Research Institute,undefined

[22] University of Cambridge,undefined

[23] Addenbrooke's Hospital,undefined

[24] Laval University,undefined

[25] Princess Margaret Cancer Centre,undefined

[26] University Health Network,undefined

[27] University of British Columbia,undefined

[28] University of British Columbia,undefined

[29] Vancouver,undefined

[30] British Columbia Cancer Agency Research Centre,undefined

[31] University of British Columbia,undefined

[32] Laboratory for Advanced Genome Analysis,undefined

[33] Vancouver Prostate Centre,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneous, and they identify a novel recurrent amplification of MYCL1.

引用

页码：736 / 745

页数：9

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