In artificial blood plasma, the electrochemical behavior of SS316L, Ni–Ti, and Ti-6Al-4V was assessed. 17–20% chromium, 13–15% nickel, 2–3% molybdenum, and trace amounts of other metals make up the composition of SS316L. 44% Titanium and 56% Nickel make up Ni–Ti. The chemical formula of Ti-6Al-4V consists primarily of titanium, with trace quantities of aluminium, vanadium, iron, and oxygen (up to 0.2%). They are frequently employed in medical implantation, particularly for inserting cardiovascular stents, due to their corrosion resistance, biocompatibility, high modulus of elasticity, and non-toxicity. Cardiac risk-free drug (CRF) is an organic cholesterol-lowering medication used by cardiac patients with stents to lower their body cholesterol. The corrosion inhibitory effect of the cardiac risk-free drug at various concentrations ranging from 50 to 150 ppm was investigated utilizing potentiodynamic polarization and electrochemical impedance spectroscopy. The Tafel slope proves the efficiency with higher linear polarisation resistance (LPR), corrosion current (Icorr) of 10.1881 × 105 Ω cm2, 3.834 × 10−5 A/cm2 respectively. Similarly, the charge transfer resistance (Rct) and double layer capacitance (Cdl) of the Nyquist plot are 1900 Ω cm2 and 0.836 × 10–9 F/cm2 respectively. With additional support provided by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and EDAX. The Inhibition Efficiency rises with increasing concentration and days, reaching a high of 99% at 150 ppm of CRF drug for 14 days on SS316L. Furthermore, it shows that adsorption on SS316L surfaces is the primary cause of the inhibitors' inhibition processes.