Adenine and uracil derivatives with antitubercular activity

被引：0
|
作者：
Alksnis E. [1 ]
Korneeva D. [1 ]
Lukevics E. [1 ]
机构：
[1] Latvian Institute of Organic Synthesis
来源：
Chemistry of Heterocyclic Compounds | 2001年 / 37卷 / 6期
关键词：
Alkylation; Purines; Pyrimidines; Tuberculosis;
D O I：
10.1023/A:1011973514672
中图分类号：
学科分类号：
摘要：
We have carried out the synthesis and investigated the antitubercular activity of adenine and 5-fluorouracil derivatives. It was found that a comparatively large, lipophilic fragment is needed in the active molecule to inhibit the tuberculosis pathogen.
引用
收藏
页码：743 / 746
页数：3
相关论文
共 50 条
  • [31] SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 4-THIAZOLIDINONE DERIVATIVES
    SOLANKEE, AN
    KAPADIA, KM
    DESAI, CM
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1992, 69 (11) : 783 - 784
  • [32] Synthesis and Antitubercular Activity of Some Novel Thiazolidinone Derivatives
    Malipeddi, Himaja
    Karigar, Asif A.
    Malipeddi, Venkata Ramana
    Sikarwar, Mukesh S.
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2012, 11 (04) : 611 - 620
  • [33] Juglone derivatives as antitubercular agents: A rationale for the activity profile
    Sharma, Smriti
    Sharma, Brij K.
    Prabhakar, Yenamandral S.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (07) : 2847 - 2853
  • [34] Synthesis and antitubercular activity of substituted novel pyrazoline derivatives
    Ali, Mohamed Ashraf
    Yary, Mohammad Shahar
    Kumar, Mahesh
    Pandian, Ganesan Suresh
    NATURAL PRODUCT RESEARCH, 2007, 21 (07) : 575 - 579
  • [35] Synthesis and in vitro antitubercular activity of some chroman derivatives
    Kushwaha, R. K.
    Singh, Kuldeep
    Chandra, D.
    Kumar, P.
    ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2022, 11 (02): : 378 - 384
  • [36] Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives
    Bate, Aaron B.
    Kalin, Jay H.
    Fooksman, Eric M.
    Amorose, Erica L.
    Price, Cristofer M.
    Williams, Heather M.
    Rodig, Michael J.
    Mitchell, Miguel O.
    Cho, Sang Hyun
    Wang, Yuehong
    Franzblau, Scott G.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (05) : 1346 - 1348
  • [37] Synthesis of benzothiazolopyrazoloisonicotinohydrazide derivatives and their nitro regioisomers for antitubercular activity
    Hazra, Kuntal
    Nandha, B.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2020, 59 (09): : 1388 - 1399
  • [38] ANTITUBERCULAR ACTIVITY OF SOME AROMATIC ALDEHYDE AND KETONE DERIVATIVES
    DATTA, AK
    DANIELS, TC
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (09) : 905 - &
  • [39] ANTITUBERCULAR ACTIVITY OF SOME 8-HYDROXYQUINOLINE DERIVATIVES
    URBANSKI, T
    SLOPEK, S
    VENULET, J
    NATURE, 1951, 168 (4262) : 29 - 29
  • [40] Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
    de Souza, Marcus V. N.
    Pais, Karla C.
    Kaiser, Carlos R.
    Peralta, Monica A.
    Ferreira, Marcelle de L.
    Lourenco, Maria C. S.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (04) : 1474 - 1480
12345