Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms

被引：0
|
作者：
Antonio Rodríguez-Blázquez
Arturo Carabias
Alba Morán-Vaquero
Sergio de Cima
Juan R. Luque-Ortega
Carlos Alfonso
Peter Schuck
José Antonio Manso
Sandra Macedo-Ribeiro
Carmen Guerrero
José M. de Pereda
机构：
[1] Universidad de Salamanca,Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)
[2] Instituto de Investigación Biomédica de Salamanca (IBSAL),Laboratory of Dynamics of Macromolecular Assembly, National Institute of Biomedical Imaging and Bioengineering
[3] Centro de Investigaciones Biológicas Margarita Salas,IBMC
[4] CSIC,Instituto de Biologia Molecular e Celular
[5] National Institutes of Health,i3S
[6] Universidade do Porto,Instituto de Investigação e Inovação em Saúde
[7] Universidade do Porto,Departamento de Medicina
[8] Universidad de Salamanca,Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences
[9] University of Copenhagen,undefined
来源：
Cell Communication and Signaling | / 21卷
关键词：
Ras-associated protein 1; RapGEF1; Signal transduction; Tyrosine phosphorylation; Src-homology 2 domain; Src-homology 3 domain;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 36 条
  • [31] Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers
    Hirata, T
    Nagai, H
    Koizumi, K
    Okino, K
    Harada, A
    Onda, M
    Nagahata, T
    Mikami, I
    Hirai, K
    Haraguchi, S
    Jin, EJ
    Kawanami, O
    Shimizu, K
    Emi, M
    JOURNAL OF HUMAN GENETICS, 2004, 49 (06) : 290 - 295
  • [32] Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers
    Tomomi Hirata
    Hisaki Nagai
    Kiyoshi Koizumi
    Keiko Okino
    Akima Harada
    Masamitsu Onda
    Takemitsu Nagahata
    Iwao Mikami
    Kyoji Hirai
    Syuji Haraguchi
    Enjing Jin
    Oichi Kawanami
    Kazuo Shimizu
    Mitsuru Emi
    Journal of Human Genetics, 2004, 49 : 290 - 295
  • [33] C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: Involvement in cell death
    Gutierrez-Uzquiza, Alvaro
    Arechederra, Maria
    Molina, Isabel
    Banos, Rocio
    Maia, Vera
    Benito, Manuel
    Guerrero, Carmen
    Porras, Almudena
    CELLULAR SIGNALLING, 2010, 22 (03) : 533 - 542
  • [34] Guanine-nucleotide exchange protein C3G activates JNK1 by a Ras-independent mechanism - JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases
    Tanaka, S
    Hanafusa, H
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (03) : 1281 - 1284
  • [35] P130Cas and CRK may regulate human CACO-2 intestinal epithelial cell migration via the small GTP binding protein Rac1 and the Guanine-Nucleotide exchange factors DOCK180 and C3G
    Sanders, Matthew A.
    Basson, Marc D.
    GASTROENTEROLOGY, 2006, 130 (04) : A150 - A150
  • [36] C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38a activation, while it impairs tumor growth through p38a-independent mechanisms
    Priego, Neibla
    Arechederra, Maria
    Sequera, Celia
    Bragado, Paloma
    Vazquez-Carballo, Ana
    Gutierrez-Uzquiza, Alvaro
    Martin-Granado, Victor
    Ventura, Juan Jose
    Kazanietz, Marcelo G.
    Guerrero, Carmen
    Porras, Almudena
    ONCOTARGET, 2016, 7 (29): : 45060 - 45078
1234