Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation

被引：0
|
作者：
Wenjie Wang
Luyao Liu
Xiaoying Hui
Ying Wang
Wenjing Ying
Qinhua Zhou
Jia Hou
Mi Yang
Bijun Sun
Jinqiao Sun
Xiaochuan Wang
机构：
[1] Children’s Hospital of Fudan University,Department of Clinical Immunology
[2] National Children’s Medical Center,undefined
来源：
BMC Immunology | / 22卷
关键词：
STAT3 transcription factor; Tocilizumab; Immune Dysregulation; Gain-of-function mutations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Treatment Options for Severe Immunodeficiency Due to Gain-of-Function STAT-1 Mutation
    Abinun, M.
    Cant, A.
    Strain, L.
    Lilic, D.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2014, 34 : S275 - S275
  • [32] A novel gain-of-function STAT3 variant in infantile-onset diabetes associated with multiorgan autoimmunity
    Zhou, Qiaoli
    Chen, Dandan
    Yu, Jing
    Zheng, Bixia
    Zhou, Wei
    Jia, Zhanjun
    Zhang, Aihua
    Gu, Wei
    MOLECULAR GENETICS & GENOMIC MEDICINE, 2024, 12 (02):
  • [33] STAT3 gain-of-function variants and T cell-mediated inflammation
    Toth, Kelsey A.
    Saucier, Nermina
    Agbigbe, Tejiri
    Schmitt, Erica
    Keppel, Molly P.
    Klechevsky, Eynav
    Kim, Brian
    Cooper, Megan A.
    JOURNAL OF IMMUNOLOGY, 2021, 206
  • [34] Investigating the Impact of Germline STAT3 Gain-of-Function on Regulatory T Cells
    Schmitt, Erica
    Keppel, Molly
    Saucier, Nermina
    Toth, Kelsey
    Vogel, Tiphanie
    Vogel, Peter
    Cooper, Megan
    JOURNAL OF CLINICAL IMMUNOLOGY, 2021, 41 (SUPPL 1) : S10 - S10
  • [35] Clinical Aspects of STAT3 Gain-of-Function Germline Mutations: A Systematic Review
    Fabre, Alexandre
    Marchal, Sarah
    Barlogis, Vincent
    Mari, Bernard
    Barbry, Pascal
    Rohrlich, Pierre-Simon
    Forbes, Lisa R.
    Vogel, Tiphanie P.
    Giovannini-Chami, Lisa
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2019, 7 (06): : 1958 - +
  • [36] Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3
    Kay Tanita
    Fumiaki Sakura
    Ryusuke Nambu
    Miyuki Tsumura
    Yusuke Imanaka
    Hidenori Ohnishi
    Zenichiro Kato
    Jie Pan
    Akihiro Hoshino
    Koji Suzuki
    Motoko Yasutomi
    Shuichiro Umetsu
    Chizuru Okada
    Masatoshi Takagi
    Kohsuke Imai
    Osamu Ohara
    Alexo M. Muise
    Satoshi Okada
    Tomohiro Morio
    Hirokazu Kanegane
    Journal of Clinical Immunology, 2021, 41 : 780 - 790
  • [37] Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3
    Tanita, Kay
    Sakura, Fumiaki
    Nambu, Ryusuke
    Tsumura, Miyuki
    Imanaka, Yusuke
    Ohnishi, Hidenori
    Kato, Zenichiro
    Pan, Jie
    Hoshino, Akihiro
    Suzuki, Koji
    Yasutomi, Motoko
    Umetsu, Shuichiro
    Okada, Chizuru
    Takagi, Masatoshi
    Imai, Kohsuke
    Ohara, Osamu
    Muise, Alexo M.
    Okada, Satoshi
    Morio, Tomohiro
    Kanegane, Hirokazu
    JOURNAL OF CLINICAL IMMUNOLOGY, 2021, 41 (04) : 780 - 790
  • [38] GAINING MORE INSIGHT INTO STAT3 GAIN-OF-FUNCTION DISEASE: A CASE PRESENTATION
    Cherk, E.
    Dimitriades, V.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2023, 131 (05) : S148 - S148
  • [39] Low IgE Is a Useful Tool to Identify STAT3 Gain-of-Function Mutations
    Johnson, Matthew B.
    Flanagan, Sarah E.
    Martins, Thomas B.
    Hill, Harry R.
    Hattersley, Andrew T.
    McDonald, Timothy J.
    CLINICAL CHEMISTRY, 2016, 62 (11) : 1536 - 1538
  • [40] Contrasting Clinical Presentations In Brothers With Identical STAT3 Gain-Of-Function Mutations
    Sachs, Jonathan W.
    Miller, Holly K.
    Wright, Benjamin L.
    Bauer, Cindy S.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (02) : AB114 - AB114
12345