HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

被引：0

作者：

Sonja I Gringhuis

Michiel van der Vlist

Linda M van den Berg

Jeroen den Dunnen

Manja Litjens

Teunis B H Geijtenbeek

机构：

[1] Center for Experimental and Molecular Medicine,Department of Molecular Cell Biology and Immunology

[2] Academic Medical Center,undefined

[3] University of Amsterdam,undefined

[4] VU University Medical Center,undefined

[5] Present address: Cell Biology and Histology,undefined

[6] Academic Medical Center,undefined

[7] University of Amsterdam,undefined

[8] Amsterdam,undefined

[9] The Netherlands.,undefined

来源：

Nature Immunology | 2010年 / 11卷

关键词：

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中图分类号：

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摘要：

HIV-1 replication requires proviral production of full-length transcripts. Geijtenbeek and colleagues show that early Tat-independent HIV-1 replication coopts innate receptor signaling by DC-SIGN and TLR8 to promote RNA polymerase II elongation complexes at long terminal repeats.

引用

页码：419 / 426

页数：7

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