Antioxidant activity of 2H-chromen-2-one derivatives

Moderate antiradical activity of 2H-chromen-2-one derivatives was established in a set of assays. The highest activity towards the superoxide radical anion (O2•–) generated in the model of enzymatic reduction of nitro blue tetrazolium was found for 4-[(1,2,3,4-tetra-hydro-1-oxonaphthalen-2-yl)(piperidin-1-yl)methyl]benzoic acid. In the non-enzymatic oxidation of epinephrine in an alkaline medium, like in other model systems, the highest activity was found for 4-(6-oxo-8,9-dihydro-6H,7H-benzo[h]-chromene[4,3-b]chromen-7-yl)benzoic acid. The absence of pronounced Fe2+-chelating activity and low reducing activity were revealed for 2H-chromen-2-one derivatives. In the model of long-lasting lipid peroxidation of tilapia liver, prolonged antioxidant effect was established for all of the test derivatives.