Antioxidant activity of 2H-chromen-2-one derivatives

被引：0

作者：

M. A. Polovinkina

V. P. Osipova

A. D. Osipova

I. V. Kanevskaya

A. L. Ivanova

N. V. Pchelintseva

N. T. Berberova

机构：

[1] Southern Scientific Center of the Russian Academy of Sciences,Federal Research Center

[2] Astrakhan State Technical University,undefined

[3] N. G. Chernyshevsky National Research Saratov State University,undefined

来源：

Russian Chemical Bulletin | 2022年 / 71卷

关键词：

2; -chromen-2-one derivatives; antioxidant activity; antiradical activity; superoxide radical anion; DPPH radical; ABTS radical cation; epinephrine; lipid peroxidation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Moderate antiradical activity of 2H-chromen-2-one derivatives was established in a set of assays. The highest activity towards the superoxide radical anion (O2•–) generated in the model of enzymatic reduction of nitro blue tetrazolium was found for 4-[(1,2,3,4-tetra-hydro-1-oxonaphthalen-2-yl)(piperidin-1-yl)methyl]benzoic acid. In the non-enzymatic oxidation of epinephrine in an alkaline medium, like in other model systems, the highest activity was found for 4-(6-oxo-8,9-dihydro-6H,7H-benzo[h]-chromene[4,3-b]chromen-7-yl)benzoic acid. The absence of pronounced Fe2+-chelating activity and low reducing activity were revealed for 2H-chromen-2-one derivatives. In the model of long-lasting lipid peroxidation of tilapia liver, prolonged antioxidant effect was established for all of the test derivatives.

引用

页码：2645 / 2653

页数：8

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