Regulatory T cells in transplantation tolerance

被引：0
|
作者：
Kathryn J. Wood
Shimon Sakaguchi
机构：
[1] University of Oxford,Nuffield Department of Surgery
[2] John Radcliffe Hospital,Department of Experimental Pathology
[3] Headington,undefined
[4] Institute of Frontier Medical Sciences,undefined
[5] Kyoto University,undefined
来源：
Nature Reviews Immunology | 2003年 / 3卷
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摘要：
Regulation by CD4+CD25+ T cells is one of the mechanisms used in vivo to both induce and maintain transplantation tolerance. Alloantigen-specific regulatory T (TReg) cells can be generated either in vivo or ex vivo. TReg cells are found in the graft, as well as in the peripheral lymphoid tissues, after transplantation. Alloantigen-specific and naturally occurring CD4+CD25+ TReg cells use similar mechanisms to control immune responsiveness in vivo. Alloantigen-specific TReg cells can be augmented by exposure to alloantigen. CD4+CD25+ TReg cells are one form of immunoregulation used to control responsiveness to alloantigens; the relationships between CD4+CD25+ TReg cells and other populations of regulatory cells remain to be clarified.
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页码：199 / 210
页数：11
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