Regulatory T cells in transplantation tolerance

被引：0
|
作者：
Kathryn J. Wood
Shimon Sakaguchi
机构：
[1] University of Oxford,Nuffield Department of Surgery
[2] John Radcliffe Hospital,Department of Experimental Pathology
[3] Headington,undefined
[4] Institute of Frontier Medical Sciences,undefined
[5] Kyoto University,undefined
来源：
Nature Reviews Immunology | 2003年 / 3卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Regulation by CD4+CD25+ T cells is one of the mechanisms used in vivo to both induce and maintain transplantation tolerance. Alloantigen-specific regulatory T (TReg) cells can be generated either in vivo or ex vivo. TReg cells are found in the graft, as well as in the peripheral lymphoid tissues, after transplantation. Alloantigen-specific and naturally occurring CD4+CD25+ TReg cells use similar mechanisms to control immune responsiveness in vivo. Alloantigen-specific TReg cells can be augmented by exposure to alloantigen. CD4+CD25+ TReg cells are one form of immunoregulation used to control responsiveness to alloantigens; the relationships between CD4+CD25+ TReg cells and other populations of regulatory cells remain to be clarified.
引用
收藏
页码：199 / 210
页数：11
相关论文
共 50 条
  • [21] Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance
    Cobbold, SP
    Graca, L
    Lin, CY
    Adams, E
    Waldmann, H
    TRANSPLANT INTERNATIONAL, 2003, 16 (02) : 66 - 75
  • [22] Regulatory T cells: tolerance induction in solid organ transplantation
    Vaikunthanathan, T.
    Safinia, N.
    Boardman, D.
    Lechler, R. I.
    Lombardi, G.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2017, 189 (02): : 197 - 210
  • [23] Regulatory T cells and transplantation tolerance: Emerging from the darkness?
    Waldmann, Herman
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2021, 51 (07) : 1580 - 1591
  • [24] Induction of regulatory T cells and transplantation tolerance by transient depletion of dividing T cells
    Barrou, Benoit
    Giraud, Sebastian
    Sebillaud, Sylvie
    Debre, Patrice
    Klatzman, David
    Thomas-Vaslin, Veronique
    TRANSPLANT INTERNATIONAL, 2007, 20 : 6 - 7
  • [25] Regulatory Cells and Transplantation Tolerance
    Cobbold, Stephen P.
    Waldmann, Herman
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2013, 3 (06):
  • [26] Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms
    Cobbold, SP
    Nolan, KF
    Graca, L
    Castejon, R
    Le Moine, A
    Frewin, M
    Humm, S
    Adams, E
    Thompson, S
    Zelenika, D
    Paterson, A
    Yates, S
    Fairchild, PJ
    Waldmann, H
    IMMUNOLOGICAL REVIEWS, 2003, 196 (01) : 109 - 124
  • [27] In vivo mechanisms leading to transplantation tolerance induced by regulatory T cells
    Golshayan, D.
    Wyss, J. -C.
    Wyss, C.
    Schaefer, S.
    Lechler, R.
    Lehr, H. -A.
    Pascual, M.
    SWISS MEDICAL WEEKLY, 2008, 138 (47-48) : 6S - 6S
  • [28] Harnessing FOXP3+ regulatory T cells for transplantation tolerance
    Waldmann, Herman
    Hilbrands, Robert
    Howie, Duncan
    Cobbold, Stephen
    JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (04): : 1439 - 1445
  • [29] Regulatory T cells: serious contenders in the promise for immunological tolerance in transplantation
    Safinia, Niloufar
    Scotta, Cristiano
    Vaikunthanathan, Trishan
    Lechler, Robert I.
    Lombardi, Giovanna
    FRONTIERS IN IMMUNOLOGY, 2015, 6
  • [30] TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance
    Lee, Kang Mi
    Stott, Ryan T.
    Zhao, Gaoping
    SooHoo, Julie
    Xiong, Wei
    Lian, Moh Moh
    Fitzgerald, Lindsey
    Shi, Shuai
    Akrawi, Elsie
    Lei, Ji
    Deng, Shaoping
    Yeh, Heidi
    Markmann, James F.
    Kim, James I.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (06) : 1728 - 1736
12345