New inhibitory signaling by CTLA-4

被引：0
|
作者：
Christoph Wülfing
Helen M Tunbridge
David C Wraith
机构：
[1] Christoph Wülfing,
[2] Helen M. Tunbridge and David C. Wraith are with the School of Cellular and Molecular Medicine,undefined
[3] University of Bristol,undefined
[4] Bristol,undefined
[5] UK.,undefined
来源：
Nature Immunology | 2014年 / 15卷
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摘要：
CTLA-4 is a potent inhibitor of T cell population expansion. The PIX-GIT2-PAK2 complex is recruited to the cytoplasmic domain of CTLA-4 via the kinase PKC-η, which suggests a previously unrecognized aspect of signal transduction via CTLA-4 in immunoregulation.
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页码：408 / 409
页数：1
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