CTLA-4: From conflict to clinic

被引：11
|
作者：
不详
机构：
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2007年 / 204卷 / 06期
关键词：
D O I：
10.1084/jem.2046fta
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as a target for antitumor therapy and as a soluble inhibitor of autoimmunity.
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页码：1243 / 1243
页数：1
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