DNA methylation in health and disease

被引：0
|
作者：
Keith D. Robertson
Alan P. Wolffe
机构：
[1] Epigenetic Gene Regulation and Cancer Section,
[2] NCI,undefined
[3] NIH,undefined
[4] Building 41,undefined
[5] Sangamo Biosciences,undefined
[6] Point Richmond Tech Center,undefined
来源：
Nature Reviews Genetics | 2000年 / 1卷
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摘要：
DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the loss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodelling enzymes, and understanding this link will be central to the design of new therapeutic tools.
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页码：11 / 19
页数：8
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