DNA methylation dynamics in health and disease

被引：403

作者：

Bergman, Yehudit ^{[1
]}

Cedar, Howard ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Med, Inst Med Res Israel Canada, Dept Dev Biol & Canc Res, IL-91010 Jerusalem, Israel

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 03期

关键词：

DE-NOVO METHYLATION; CELL-SPECIFIC DEMETHYLATION; CPG ISLAND METHYLATION; ACTIVE DEMETHYLATION; HISTONE H3; EPIGENETIC INHERITANCE; DEVELOPMENTAL PATTERN; CHROMATIN-STRUCTURE; TUMOR-SUPPRESSOR; PATERNAL GENOME;

D O I：

10.1038/nsmb.2518

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation is an epigenetic mark that is erased in the early embryo and then reestablished in each individual, through a developmentally regulated program mediated by sequence information and trans-acting factors that direct the de novo DNA methylation and demethylation machinery to its targets in a dynamic manner. Once established, these patterns can be maintained in a stable manner over the lifetime of the organism. Additional changes in methylation that occur during aging and as part of disease processes may also be directed by similar molecular rules using the same complex machinery.

引用

页码：274 / 281

页数：8

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