FBXW5 controls centrosome number

被引:0
|
作者
Julia Pagan
Michele Pagano
机构
[1] NYU Cancer Institute,Julia Pagan and Michele Pagano are in the Department of Pathology
[2] New York University School of Medicine,undefined
[3] 522 First Avenue,undefined
[4] SRB 1107,undefined
[5] New York,undefined
[6] New York 10016,undefined
[7] USA,undefined
[8] Michele Pagano is at the Howard Hughes Medical Institute,undefined
[9] 4000 Jones Bridge Road Chevy Chase,undefined
[10] Maryland 20815-6789,undefined
[11] USA,undefined
来源
Nature Cell Biology | 2011年 / 13卷
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摘要
Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.
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页码:888 / 890
页数:2
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