FBXW5 controls centrosome number

被引：0

作者：

Julia Pagan

Michele Pagano

机构：

[1] NYU Cancer Institute,Julia Pagan and Michele Pagano are in the Department of Pathology

[2] New York University School of Medicine,undefined

[3] 522 First Avenue,undefined

[4] SRB 1107,undefined

[5] New York,undefined

[6] New York 10016,undefined

[7] USA,undefined

[8] Michele Pagano is at the Howard Hughes Medical Institute,undefined

[9] 4000 Jones Bridge Road Chevy Chase,undefined

[10] Maryland 20815-6789,undefined

[11] USA,undefined

来源：

Nature Cell Biology | 2011年 / 13卷

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摘要：

Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.

引用

页码：888 / 890

页数：2

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