The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

被引：0
|
作者：
Anja Puklowski
Yahya Homsi
Debora Keller
Martin May
Sangeeta Chauhan
Uta Kossatz
Viktor Grünwald
Stefan Kubicka
Andreas Pich
Michael P. Manns
Ingrid Hoffmann
Pierre Gönczy
Nisar P. Malek
机构：
[1] Institute for Molecular Biology,Department of Hematology
[2] Hannover Medical School,Department of Gastroenterology
[3] School of Life Sciences,undefined
[4] Swiss Federal Institute of Technology (EPFL),undefined
[5] Swiss Institute for Experimental Cancer Research (ISREC),undefined
[6] Institute of Pharmacology and Toxicology,undefined
[7] Hannover Medical School,undefined
[8] Hannover Medical School,undefined
[9] Hepatology and Endocrinology,undefined
[10] Hannover Medical School,undefined
[11] German Cancer Research Center,undefined
[12] DKFZ,undefined
来源：
Nature Cell Biology | 2011年 / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The PLK4 kinase and centrosomal protein HsSAS-6 both regulate centrosome duplication. PLK4 negatively controls an FBXW5-containing ubiquitin ligase, which targets SAS-6 for destruction to restrict centrosome re-duplication.
引用
收藏
页码：1004 / 1009
页数：5
相关论文
共 6 条
  • [1] The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
    Puklowski, Anja
    Homsi, Yahya
    Keller, Debora
    May, Martin
    Chauhan, Sangeeta
    Kossatz, Uta
    Gruenwald, Viktor
    Kubicka, Stefan
    Pich, Andreas
    Manns, Michael P.
    Hoffmann, Ingrid
    Goenczy, Pierre
    Malek, Nisar P.
    NATURE CELL BIOLOGY, 2011, 13 (08) : 1004 - U291
  • [2] The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication
    Badarudeen, Binshad
    Gupta, Ria
    Nair, Sreeja, V
    Chandrasekharan, Aneesh
    Manna, Tapas K.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (14) : 4428 - 4437
  • [3] The E3 ubiquitin ligase Cul4/DDB1/DCAF5 regulates Plk4 protein levels and inhibits centriole duplication
    Hoffmann, I. M.
    Kratz, A.
    Freiss, S.
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [4] The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage
    Haenle-Kreidler, Simon
    Richter, Kai T.
    Hoffmann, Ingrid
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298 (12)
  • [5] The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage
    Hänle-Kreidler, Simon
    Richter, Kai T.
    Hoffmann, Ingrid
    Journal of Biological Chemistry, 2022, 298 (12)
  • [6] The Stability of Histone Acetyltransferase General Control Non-derepressible (Gcn) 5 Is Regulated by Cullin4-RING E3 Ubiquitin Ligase
    Li, Yongming
    Jaramillo-Lambert, Aimee
    Hao, Jing
    Yang, Yi
    Zhu, Wenge
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (48) : 41344 - 41352
1