Two are better than one

被引：0

作者：

Stephen E. Halford

Darren M. Gowers

Richard B. Sessions

机构：

[1] School of Medical Sciences,the Department of Biochemistry

[2] University of Bristol,undefined

[3] University Walk,undefined

来源：

Nature Structural Biology | 2000年 / 7卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A crystal structure of a tetrameric restriction enzyme, NgoMIV, bound to two DNA duplexes has been determined. Two subunits contact each duplex in much the same manner as a dimeric restriction enzyme recognizing a single site, but the dimeric units are packed back-to-back, placing the duplexes on opposite sides of the tetramer. Interaction with two recognition sites, presumably via looping, enhances NgoMIV activity.

引用

页码：705 / 707

页数：2

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