Two are better than one

被引：0
|
作者：
Stephen E. Halford
Darren M. Gowers
Richard B. Sessions
机构：
[1] School of Medical Sciences,the Department of Biochemistry
[2] University of Bristol,undefined
[3] University Walk,undefined
来源：
Nature Structural Biology | 2000年 / 7卷
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摘要：
A crystal structure of a tetrameric restriction enzyme, NgoMIV, bound to two DNA duplexes has been determined. Two subunits contact each duplex in much the same manner as a dimeric restriction enzyme recognizing a single site, but the dimeric units are packed back-to-back, placing the duplexes on opposite sides of the tetramer. Interaction with two recognition sites, presumably via looping, enhances NgoMIV activity.
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页码：705 / 707
页数：2
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