Increasing the solubility of phenazepam by forming solid dispersions

被引：0
|
作者：
I. I. Krasnyuk
O. V. Manakhova
R. U. Khabriev
V. A. Popkov
V. Yu. Reshetnyak
O. I. Krasnyuk
机构：
[1] Sechenov Moscow Medical Academy,
来源：
Pharmaceutical Chemistry Journal | 2010年 / 44卷
关键词：
solid dispersion; solubility; phenazepam; poly(ethyleneglycol)-1500; poly(vinylpyrrolidone)-10000; β-cyclodextrin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of solid dispersion (SD) formation on the solubility of phenazepam has been studied. Phenazepam and its SDs with poly(ethyleneglycol)-1500 (PEG), poly(vinylpyrrolidone)-10000 (PVP), and β-cyclodextrin were studied. The SD with PVP increases both the solubility and the dissolution rate of phenazepam. Results obtained by a complex of physical and chemical methods suggest that the improved release of phenazepam from the SD with PVP is due to solubilization, amorphization, and formation of a colloidal dispersion of the parent drug substance.
引用
收藏
页码：274 / 277
页数：3
相关论文
共 50 条
  • [21] Solubility Advantage (and Disadvantage) of Pharmaceutical Amorphous Solid Dispersions
    Huang, Siyuan
    Mao, Chen
    Williams, Robert O., III
    Yang, Chia-Yi
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 105 (12) : 3549 - 3561
  • [22] Improving the solubility of ampelopsin by solid dispersions and inclusion complexes
    Ruan, LP
    Yu, BY
    Fu, GM
    Zhu, DN
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 38 (03) : 457 - 464
  • [23] Solid dispersions enhance solubility, dissolution, and permeability of thalidomide
    Barea, Silvana A.
    Mattos, Cristiane B.
    Cruz, Ariadne C. C.
    Chaves, Vitor C.
    Pereira, Rafael N.
    Simoes, Claudia M. O.
    Kratz, Jadel M.
    Koester, Leticia S.
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2017, 43 (03) : 511 - 518
  • [24] Study of the Solubility of Furazolidone from Solid Dispersions with Polyvinylpyrrolidone
    A. V. Beliatskaya
    I. I. Krasnyuk
    A. O. Elagina
    I. I. Krasnyuk
    I. M. Kashlikova
    O. I. Stepanova
    A. N. Vorob’yov
    A. N. Kuzmenko
    S. G. Iskenderova
    D. R. Kannieva
    Moscow University Chemistry Bulletin, 2020, 75 : 43 - 46
  • [25] SOLUBILITY OF DICLOFENAC ACID FORM FROM SOLID DISPERSIONS
    Krasnyuk, I. I., Jr.
    Ovsyannikova, L. V.
    Nikulina, O. I.
    Belyatskaya, A. V.
    Krasnyuk, I. I.
    Kharitonov, Yu. Ya.
    Grikh, V. V.
    Korol', L. A.
    Obidchenko, Yu. A.
    Vorob'ev, A. N.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 48 (11) : 735 - 739
  • [26] Solubility of Diclofenac Acid Form from Solid Dispersions
    I. I. Krasnyuk
    L. V. Ovsyannikova
    O. I. Nikulina
    A. V. Belyatskaya
    I. I. Krasnyuk
    Yu. Ya. Kharitonov
    V. V. Grikh
    L. A. Korol’
    Yu. A. Obidchenko
    A. N. Vorob’ev
    Pharmaceutical Chemistry Journal, 2015, 48 : 733 - 737
  • [27] Characterization and solubility study of solid dispersions of flunarizine and polyvinylpyrrolidone
    Marín, MT
    Margarit, MV
    Salcedo, GE
    FARMACO, 2002, 57 (09): : 723 - 727
  • [28] Study of the Solubility of Furazolidone from Solid Dispersions with Polyvinylpyrrolidone
    Beliatskaya, A. V.
    Krasnyuk, I. I., Jr.
    Elagina, A. O.
    Krasnyuk, I. I.
    Kashlikova, I. M.
    Stepanova, O. I.
    Vorob'yov, A. N.
    Kuzmenko, A. N.
    Iskenderova, S. G.
    Kannieva, D. R.
    MOSCOW UNIVERSITY CHEMISTRY BULLETIN, 2020, 75 (01) : 43 - 46
  • [29] Microstructured ternary solid dispersions to improve carbamazepine solubility
    Martins, Rodrigo M.
    Siqueira, Silvia
    Tacon, Luciana A.
    Freitas, Luis A. P.
    POWDER TECHNOLOGY, 2012, 215-16 : 156 - 165
  • [30] Solubility advantage from amorphous etoricoxib solid dispersions
    Dani, Prateek
    Puri, Vibha
    Bansal, A. K.
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2014, 40 (01) : 92 - 101
12345