Solubility of Diclofenac Acid Form from Solid Dispersions

被引：0

作者：

I. I. Krasnyuk

L. V. Ovsyannikova

O. I. Nikulina

A. V. Belyatskaya

I. I. Krasnyuk

Yu. Ya. Kharitonov

V. V. Grikh

L. A. Korol’

Yu. A. Obidchenko

A. N. Vorob’ev

机构：

[1] Sechenov First Moscow State Medical University,Research and Education Center of Collective Use

[2] People’s Friendship University of Russia,undefined

来源：

Pharmaceutical Chemistry Journal | 2015年 / 48卷

关键词：

solid dispersions; solubility; NSAID; diclofenac; polyethyleneglycol-1500; polyvinylpyrrolidone-10000; crystallinity; bioavailability;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The influence of solid dispersions (SD) on diclofenac solubility was determined by studying diclofenac (acid form) and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP). SD formation increased the solubility and dissolution rate of the non-steroidal anti-inflammatory drug (NSAID). Diclofenac solubility from the SD with PVP increased by 2.5 times; from the SD with PEG (solvent evaporation method), by 8 times compared with diclofenac drug substance. A combination of physicochemical methods showed that the improved release of diclofenac from the SD occurred because of reduced crystallinity, formation of drug solid solutions in the polymer matrix, and formation of a colloidal drug solution.

引用

页码：733 / 737

页数：4

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