We consider a Gaussian diffusion Xt (Ornstein-Uhlenbeck process) with drift coefficient γ and diffusion coefficient σ2, and an approximating process \documentclass[12pt]{minimal}
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\begin{document}$Y^{\varepsilon}_{t}$\end{document} converging to Xt in L2 as ε→0. We study estimators \documentclass[12pt]{minimal}
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\begin{document}$\hat{\gamma}_{\varepsilon}$\end{document}, \documentclass[12pt]{minimal}
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\begin{document}$\hat{\sigma}^{2}_{\varepsilon}$\end{document} which are asymptotically equivalent to the Maximum likelihood estimators of γ and σ2, respectively. We assume that the estimators are based on the available N=N(ε) observations extracted by sub-sampling only from the approximating process \documentclass[12pt]{minimal}
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\begin{document}$Y^{\varepsilon}_{t}$\end{document} with time step Δ=Δ(ε). We characterize all such adaptive sub-sampling schemes for which \documentclass[12pt]{minimal}
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\begin{document}$\hat{\gamma}_{\varepsilon}$\end{document}, \documentclass[12pt]{minimal}
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\begin{document}$\hat{\sigma}^{2}_{\varepsilon}$\end{document} are consistent and asymptotically efficient estimators of γ and σ2 as ε→0. The favorable adaptive sub-sampling schemes are identified by the conditions ε→0, Δ→0, (Δ/ε)→∞, and NΔ→∞, which implies that we sample from the process \documentclass[12pt]{minimal}
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\begin{document}$Y^{\varepsilon}_{t}$\end{document} with a vanishing but coarse time step Δ(ε)≫ε. This study highlights the necessity to sub-sample at adequate rates when the observations are not generated by the underlying stochastic model whose parameters are being estimated. The adequate sub-sampling rates we identify seem to retain their validity in much wider contexts such as the additive triad application we briefly outline.