Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

被引：0
|
作者：
Alvin P Makohon-Moore
Ming Zhang
Johannes G Reiter
Ivana Bozic
Benjamin Allen
Deepanjan Kundu
Krishnendu Chatterjee
Fay Wong
Yuchen Jiao
Zachary A Kohutek
Jungeui Hong
Marc Attiyeh
Breanna Javier
Laura D Wood
Ralph H Hruban
Martin A Nowak
Nickolas Papadopoulos
Kenneth W Kinzler
Bert Vogelstein
Christine A Iacobuzio-Donahue
机构：
[1] Sol Goldman Pancreatic Cancer Research Center,Department of Pathology
[2] Johns Hopkins University School of Medicine,Department of Mathematics
[3] Johns Hopkins University School of Medicine,Department of Mathematics
[4] Ludwig Center,Department of Radiation Oncology
[5] Johns Hopkins University School of Medicine,Department of Oncology
[6] IST Austria (Institute of Science and Technology Austria),Department of Organismic and Evolutionary Biology
[7] Program for Evolutionary Dynamics,Department of Pathology
[8] Harvard University,undefined
[9] Harvard University,undefined
[10] Center for Mathematical Sciences and Applications,undefined
[11] Harvard University,undefined
[12] Emmanuel College,undefined
[13] Memorial Sloan Kettering Cancer Center,undefined
[14] David M. Rubenstein Center for Pancreatic Cancer Research,undefined
[15] Human Oncology and Pathogenesis Program,undefined
[16] Memorial Sloan Kettering Cancer Center,undefined
[17] Johns Hopkins University School of Medicine,undefined
[18] Harvard University,undefined
[19] Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center,undefined
[20] Memorial Sloan Kettering Cancer Center,undefined
[21] Present address: David M. Rubenstein Center for Pancreatic Cancer Research,undefined
[22] Human Oncology and Pathogenesis Program,undefined
[23] Memorial Sloan Kettering Cancer Center,undefined
[24] New York,undefined
[25] New York,undefined
[26] USA.,undefined
来源：
Nature Genetics | 2017年 / 49卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient primary tumors and metastases have identical mutations in known driver genes.
引用
收藏
页码：358 / 366
页数：8
相关论文
共 50 条
  • [41] STK11 GENE MUTATIONS AMONG PATIENTS WITH SPORADIC BREAST CANCER
    Antov, Georgi
    Krasteva, Maria
    Andonova, Silvia
    Savov, Alexey
    Angelova, Svetla
    Stoilov, Lubomir
    Toncheva, Draga
    GENETIKA-BELGRADE, 2017, 49 (02): : 399 - 413
  • [42] Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients
    Syrjäkoski, K
    Fredriksson, H
    Ikonen, T
    Kuukasjärvi, T
    Autio, V
    Matikainen, MP
    Tammela, TLJ
    Koivistol, PA
    Schleutker, J
    INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (02) : 518 - 520
  • [43] Gefitinib treatment for brain metastases in patients with EGFR gene mutations
    Kate Matthews
    Nature Clinical Practice Neurology, 2006, 2 (5): : 236 - 236
  • [44] Validated Limited Gene Predictor For Cervical Cancer Lymph Node Metastases
    Bloomstein, J.
    Von Eyben, R.
    Rankin, E.
    Wang-Chiang, J.
    David, S. MacLaughlan
    Esfahani, M. Shahrokh
    Kidd, E. A.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2019, 105 (01): : S50 - S50
  • [45] Approach to Patients With Pancreatic Cancer Without Detectable Metastases
    Heestand, Gregory M.
    Murphy, James D.
    Lowy, Andrew M.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (16) : 1770 - +
  • [46] Phenotypic heterogeneity in patients with mutations in the IGHMBP2 gene
    Gomez-Garcia de la Banda, M.
    Felipe-Rucian, A.
    Gomez, D.
    Gratacos, M.
    Sanchez-Montanez, A.
    Gran, F.
    Bernal, S.
    Tizzano, E.
    Gamez, J.
    Munell, F.
    NEUROMUSCULAR DISORDERS, 2017, 27 : S135 - S135
  • [47] Heterogeneity of mutations in the ferrochelatase gene in Italian patients with erythropoietic protoporphyria
    Aurizi, Caterina
    Schneider-Yin, Xiaoye
    Sorge, Fiammetta
    Macri, Annelisa
    Minder, Elisabeth I.
    Biolcati, Gianfranco
    MOLECULAR GENETICS AND METABOLISM, 2007, 90 (04) : 402 - 407
  • [48] Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis
    Merid, Simon Kebede
    Goranskaya, Daria
    Alexeyenko, Andrey
    BMC BIOINFORMATICS, 2014, 15
  • [49] Asymmetry of visual evoked potentials in albino patients with known gene mutations
    Wagner, SP
    VerHoeve, JN
    Spritz, RA
    France, TD
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 4981 - 4981
  • [50] Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis
    Simon Kebede Merid
    Daria Goranskaya
    Andrey Alexeyenko
    BMC Bioinformatics, 15
12345