Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

被引：0
|
作者：
Alvin P Makohon-Moore
Ming Zhang
Johannes G Reiter
Ivana Bozic
Benjamin Allen
Deepanjan Kundu
Krishnendu Chatterjee
Fay Wong
Yuchen Jiao
Zachary A Kohutek
Jungeui Hong
Marc Attiyeh
Breanna Javier
Laura D Wood
Ralph H Hruban
Martin A Nowak
Nickolas Papadopoulos
Kenneth W Kinzler
Bert Vogelstein
Christine A Iacobuzio-Donahue
机构：
[1] Sol Goldman Pancreatic Cancer Research Center,Department of Pathology
[2] Johns Hopkins University School of Medicine,Department of Mathematics
[3] Johns Hopkins University School of Medicine,Department of Mathematics
[4] Ludwig Center,Department of Radiation Oncology
[5] Johns Hopkins University School of Medicine,Department of Oncology
[6] IST Austria (Institute of Science and Technology Austria),Department of Organismic and Evolutionary Biology
[7] Program for Evolutionary Dynamics,Department of Pathology
[8] Harvard University,undefined
[9] Harvard University,undefined
[10] Center for Mathematical Sciences and Applications,undefined
[11] Harvard University,undefined
[12] Emmanuel College,undefined
[13] Memorial Sloan Kettering Cancer Center,undefined
[14] David M. Rubenstein Center for Pancreatic Cancer Research,undefined
[15] Human Oncology and Pathogenesis Program,undefined
[16] Memorial Sloan Kettering Cancer Center,undefined
[17] Johns Hopkins University School of Medicine,undefined
[18] Harvard University,undefined
[19] Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center,undefined
[20] Memorial Sloan Kettering Cancer Center,undefined
[21] Present address: David M. Rubenstein Center for Pancreatic Cancer Research,undefined
[22] Human Oncology and Pathogenesis Program,undefined
[23] Memorial Sloan Kettering Cancer Center,undefined
[24] New York,undefined
[25] New York,undefined
[26] USA.,undefined
来源：
Nature Genetics | 2017年 / 49卷
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摘要：
Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient primary tumors and metastases have identical mutations in known driver genes.
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页码：358 / 366
页数：8
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