Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

被引：0

作者：

Alvin P Makohon-Moore

Ming Zhang

Johannes G Reiter

Ivana Bozic

Benjamin Allen

Deepanjan Kundu

Krishnendu Chatterjee

Fay Wong

Yuchen Jiao

Zachary A Kohutek

Jungeui Hong

Marc Attiyeh

Breanna Javier

Laura D Wood

Ralph H Hruban

Martin A Nowak

Nickolas Papadopoulos

Kenneth W Kinzler

Bert Vogelstein

Christine A Iacobuzio-Donahue

机构：

[1] Sol Goldman Pancreatic Cancer Research Center,Department of Pathology

[2] Johns Hopkins University School of Medicine,Department of Mathematics

[3] Johns Hopkins University School of Medicine,Department of Mathematics

[4] Ludwig Center,Department of Radiation Oncology

[5] Johns Hopkins University School of Medicine,Department of Oncology

[6] IST Austria (Institute of Science and Technology Austria),Department of Organismic and Evolutionary Biology

[7] Program for Evolutionary Dynamics,Department of Pathology

[8] Harvard University,undefined

[9] Harvard University,undefined

[10] Center for Mathematical Sciences and Applications,undefined

[11] Harvard University,undefined

[12] Emmanuel College,undefined

[13] Memorial Sloan Kettering Cancer Center,undefined

[14] David M. Rubenstein Center for Pancreatic Cancer Research,undefined

[15] Human Oncology and Pathogenesis Program,undefined

[16] Memorial Sloan Kettering Cancer Center,undefined

[17] Johns Hopkins University School of Medicine,undefined

[18] Harvard University,undefined

[19] Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center,undefined

[20] Memorial Sloan Kettering Cancer Center,undefined

[21] Present address: David M. Rubenstein Center for Pancreatic Cancer Research,undefined

[22] Human Oncology and Pathogenesis Program,undefined

[23] Memorial Sloan Kettering Cancer Center,undefined

[24] New York,undefined

[25] New York,undefined

[26] USA.,undefined

来源：

Nature Genetics | 2017年 / 49卷

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学科分类号：

摘要：

Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient primary tumors and metastases have identical mutations in known driver genes.

引用

页码：358 / 366

页数：8

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