Polyacrylates of noble metals as potential antitumor drugs

被引：0

作者：

Ostrovskaya L.A. ^{[1
]}

Voronkov M.G. ^{[2
]}

Korman D.B. ^{[1
]}

Bluhterova N.V. ^{[1
]}

Fomina M.M. ^{[1
]}

Rikova V.A. ^{[1
]}

Abzaeva K.A. ^{[2
]}

Zhilitskaya L.V. ^{[2
]}

机构：

[1] Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow

[2] Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk

来源：

Biophysics | 2014年 / 59卷 / 4期

关键词：

experimental antitumor chemotherapy; polyacrylates of noble metals; transplantable murine tumor models;

D O I：

10.1134/S0006350914040216

中图分类号：

学科分类号：

摘要：

The antitumor activity of polyacrylates of the noble metals containing argentum (argacryl), aurum (auracryl) and platinum (platacryl) has been studied using experimental murine solid tumor models (Lewis lung carcinoma and Acatol adenocarcinoma). It has been found that polyacrylates of the noble metals are capable of inhibiting tumor development by 50–90% compared to control. Auracryl that inhibits the growth of Lewis lung carcinoma and Acatol adenocarcinoma by 80 and 90%, respectively, compared to control is the most efficient among the tested compounds and can be recommended for the further profound preclinical studies. © 2014, Pleiades Publishing, Inc.

引用

页码：642 / 645

页数：3

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